Table 3.
Comparison of symptom severity at enrollment by adenovirus type
| Species C N = 21 | Non‐species C N = 12 | P‐value | |||
|---|---|---|---|---|---|
| Median, N | Median, N | All | Children | Adults | |
| Upper respiratory symptoms | |||||
| Sneezing | 1·00 (21) | 0·0 (12) | 0·72 | 0·35 | 0·25 |
| Sore throat | 0·00 (10) | 3·0 (9) | 0·003 | 0·07 | 0·79 |
| Earache | 0·0 (10) | 0·0 (9) | 0·39 | 0·13 | 0·25 |
| Rhinorrhea | 2·00 (21) | 1·0 (12) | 0·77 | 0·98 | 1·00 |
| Cough | 1·00 (21) | 1·0 (12) | 0·55 | 0·70 | 0·80 |
| Hoarseness | 0·00 (21) | 1·0 (12) | 0·03 | 0·10 | 0·46 |
| Lower respiratory symptoms | |||||
| Shortness of breath | 0·00 (19) | 0·0 (12) | 0·30 | 0·10 | 0·77 |
| Chest pain | 0·0 (10) | 0·0 (9) | 0·04 | 1·00 | 0·60 |
| Gastroenteritis symptoms | |||||
| Decreased appetite | 2·00 (21) | 1·0 (12) | 0·73 | 0·85 | 0·62 |
| Vomiting | 0·00 (21) | 0·0 (12) | 0·91 | 0·86 | 1·00 |
| Diarrhea | 0·00 (21) | 0·0 (12) | 0·59 | 0·46 | 0·76 |
| Abdominal pain | 0·00 (11) | 0·0 (9) | 0·57 | 0·53 | 0·58 |
| Systemic symptoms | |||||
| Headache | 0·00 (10) | 1·0 (9) | 0·009 | 0·14 | 0·58 |
| Red eyes | 0·00 (21) | 0·0 (12) | 0·41 | 0·96 | 0·58 |
| Chills | 0·00 (20) | 1·0 (12) | 0·09 | 0·79 | 0·46 |
| Nausea | 0·00 (10) | 0·0 (9) | 0·92 | 0·51 | 0·60 |
| Joint pain | 0·00 (7) | 1·0 (9) | 0·02 | 0·27 | NA |
| Muscle aches | 0 (10) | 1·5 (9) | 0·008 | 0·13 | 0·31 |
| Fatigue | 2·00 (21) | 2·0 (12) | 0·13 | 0·53 | 1·00 |
| Dizziness | 0·00 (10) | 0·50 (9) | 0·44 | 0·81 | 0·80 |
| Composite severity score (ARIC original), Med (IQR) | |||||
| Respiratory symptom score | 1·0 (1·5–1·0) | 1·3 (0·85–1·6) | 0·12 | 0·76 | 0·61 |
| Systemic symptom score | 1·0 (0·2–1·0) | 1·2 (0·9–2·2) | 0·03 | 0·44 | 0·30 |
| Modified Hayden severity score, Med (IQR)a | |||||
| Upper respiratory | 2 (0–5) | 4 (3–4) | 0·40 | 0·37 | 0·26 |
| Lower respiratory | 1 (1–2) | 3 (1–4) | 0·40 | 1·00 | 0·61 |
| Systemic | 4 (0–11) | 6 (6–10) | 0·64 | 0·77 | 0·29 |
| Total | 7 (2–17) | 14 (11–17) | 0·31 | 0·39 | 0·80 |
a
Definitions of Hayden severity score are as follows: upper respiratory symptom—earache, runny nose, sore throat, and sneezing; lower respiratory symptom—cough, breathing difficulty, hoarseness, and chest pain; systemic symptom—muscle ache, fatigue, headache, and chills; total—all of the above. Symptoms were collected by interview. Severity was ranked on a four‐point scale ranging from none (0) to severe (3). The number of people asked about particular symptoms is reported in parentheses. P‐values from Wilcoxon rank‐sum tests comparing distributions of scores by adenovirus species and by age‐group.