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. 2016 Jun 22;59(13):6149–6168. doi: 10.1021/acs.jmedchem.6b00044

Figure 3.

Figure 3

Biological characterization of triazole derivatives. Flow cytometric analysis (A) of the binding of selected triazolyl derivatives in comparison to reference naphthoic acid derivative 3 at the P2Y14R expressed in CHO cells, as detected through inhibition of fluorescent cell labeling with 4. Concentration–response curves for selected compounds (B) displayed a smooth concentration dependence of the inhibition. The IC50 values are given in Table 3. (C) Effects of P2Y14R antagonist 65 on cAMP levels in P2Y14R-expressing CHO cells.