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. 2016 Jun 22;59(13):6149–6168. doi: 10.1021/acs.jmedchem.6b00044

Table 3. Potencies of P2Y14R Antagonists in Flow Cytometry Assay Determined with Full Concentration–Response Curves.

compd P2Y14R potency, IC50 (nM)a
3 6.0 ± 0.1
65 31.7 ± 8.0
70 290 ± 88
71 115 ± 15
75 91 ± 4
76 237 ± 90
77 72.4 ± 14.0
78 481 ± 81
79 224 ± 64
82 162 ± 25
84 131 ± 39
90 228 ± 63
a

Percent inhibition of binding of fluorescent antagonist 4 (20 nM) in P2Y14R-CHO cells (n = 3), over a concentration range of 10–9 to 10–5 M.