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. 2016 May 12;7(7):697–701. doi: 10.1021/acsmedchemlett.6b00122

Table 3. ROMK and hERG Activity of Stereoisomers of 10 (in μM).

compd 12 13 16
ROMK 86Rb+ efflux 0.068 0.134 0.112
ROMK Tl+ flux 0.006 0.059 0.010
ROMK EP 0.009 0.012 0.009
hERG binding 23 47 100
hERG EP 22 22 >30
hERG EP/ROMK EP 2440 1800 >3000