Table 5. Acute (4 h) Diuresis/Natriuresis of Isomers of 10 in SD Rat^a after Oral Dosing.

compd	dose	diuresis fold increaseb	natriuresis fold increaseb	kaliuresis fold increaseb
12	0.3 mg/kg	6.4d	6.2d	2.1c
12	1 mg/kg	8.6d	8.6d	1.8
12	3 mg/kg	9.0d	8.0d	1.4
12	10 mg/kg	9.4d	8.5d	1.7
13	0.3 mg/kg	1.3	1.4	1.1
13	1 mg/kg	1.6	1.5	1.0
13	3 mg/kg	1.9	2.2	0.9
16	1 mg/kg	3.5d	3.7d	1.3
16	3 mg/kg	4.5d	4.1d	1.1

^an = 5 per group.

^bCompared to vehicle.

^cp < 0.01 vs. vehicle.

^dp < 0.05 vs. vehicle.