Table 3. Exploration of the Cyclic Ether Group at the 5-Position.

^aThe estimated coefficients of variation for the EC₅₀, S_0.5, and V_max are 30% (n = 383), 17% (n = 297), and 4% (n = 329), respectively, based on the performance of a reference compound. Also, human recombinant GK was used in all the assays.

^bRat IV dose: 0.5 mg/kg, n = 3.

^cRacemic, a pair of cis isomers; in addition, all stereochemistry was assigned arbitrarily.