Table 2. Association of HOXB13 p.G84E and p.R217C with breast cancer risk.
| Variant | Study |
Carrier allele frequency |
OR (95% CI) | P-value | |
|---|---|---|---|---|---|
| Controls | Cases | ||||
| c.251G > A/p.G84E | RBCS | 3/356 (0.84%) | 9/1,465 (0.61%) | ||
| ABCS-F | 13/1,944 (0.67%) | 9/1,722 (0.52%) | |||
| Combined | 16/2,300(0.70%) | 18/3,187 (0.56%) | 0.81 (0.41–1.59) | 0.54 | |
| c.649C > T/p.R217C | RBCS | 0/355 (0%) | 5/1,473 (0.34%) | ||
| ABCS-F | 2/1,933 (0.10%) | 5/1,735 (0.29%) | |||
| Combined | 2/2,288 (0.087%) | 10/3,208 (0.31%) | 3.57 (0.76–33.57) | 0.14 | |
OR: odds ratio, CI: confidence interval.