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. 2016 Jul 11;148(4):407–419. doi: 10.1111/imm.12619

Figure 7.

Figure 7

C5a/C5aR1 signalling causes endothelial cell apoptosis through the caspase 1/8 pathway. Expression of (a) caspase 1 (Casp‐1), (b) Casp‐8, (c) Casp‐4 and (d) Casp‐10 were assessed in human brain microvascular endothelial cells (HBMVECs) treated with C5a, lupus serum alone and in combination with C5aRa. Treatment with lupus serum significantly increased Casp‐1 and Casp‐8 gene expression levels in HBMVEC cells, whereas no significant differences were observed in Casp‐4 and Casp‐10 gene expression levels. All statistical comparisons were made to the untreated controls. Results are expressed as the mean ± SD from n = 3 separate experiments. P < 0·05 is considered statistically significant.