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. 2016 Jun 29;148(4):326–338. doi: 10.1111/imm.12611

Figure 1.

Figure 1

MicroRNA (miR) 223 was significantly up‐regulated in spinal cords and peripheral lymphoid tissues but not in non‐lymphoid tissues in experimental autoimmune encephalomyelitis (EAE)‐bearing mice. At day 14 post‐MOG immunization, mice were killed and tissues were collected for cell or RNA isolation followed by quantification of miRs by real‐time quantitative PCR. (a) Expression of miR223 and miR155 in spinal cords was induced during EAE analysis. (b) miR124 expression was suppressed during EAE. (c) miR223 expression was induced by EAE in central nervous system and peripheral lymphoid tissues. (d) miR223 expression in CD4+ and CD11b+ cells purified from the spleens was increased during EAE. Results are representative of three independent experiments. Data represent the mean ± SEM (n = 4, *P < 0·05, **P < 0·01, ***P < 0·001).