Table 3.
Change in plasma concentrations of angiogenesis-related proteins (Luminex) from pre-transplant to 1 year post-transplant is associated with the development of CAV by IVUS
| Univariate |
Multivariate |
||||||
|---|---|---|---|---|---|---|---|
| Parameter | n | OR | 95% CI | p-value | OR | 95% CI | p-value |
| Change in Angiopoietin-2 | 46 | 1.50 | 0.22–10.49 | 0.680 | |||
| Change in BMP-9 | 46 | 1.11 | 0.21–5.90 | 0.906 | |||
| Change in EGF | 46 | 2.01 | 0.51–7.98 | 0.319 | |||
| Change in Endoglin | 46 | 0.86 | 0.36–2.08 | 0.738 | |||
| Change in Endothelin-1 | 46 | 0.50 | 0.21–1.20 | 0.119 | 0.20 | 0.06–0.71 | 0.012 |
| Change in FGF-1 | 46 | 3.45 | 0.47–25.17 | 0.221 | 14.11 | 1.06–188.22 | 0.045 |
| Change in FGF-2 | 46 | 3.74 | 0.08–168.41 | 0.497 | |||
| Change in Follistatin | 46 | 0.80 | 0.25–2.56 | 0.704 | |||
| Change in G-CSF | 46 | 0.78 | 0.30–2.01 | 0.606 | |||
| Change in HB-EGF | 46 | 5.25 | 0.20–138.31 | 0.320 | |||
| Change in HGF | 46 | 0.45 | 0.18–1.17 | 0.103 | |||
| Change in IL-8 | 46 | 1.10 | 0.53–2.26 | 0.803 | |||
| Change in Leptin | 46 | 1.89 | 0.37–9.66 | 0.442 | |||
| Change in PLGF | 46 | 1.06 | 0.55–2.05 | 0.860 | |||
| Change in VEGF-A | 46 | 1.20 | 0.61–2.37 | 0.599 | |||
| Change in VEGF-C | 46 | 1.69 | 0.86–3.33 | 0.128 | 2.68 | 1.15–6.23 | 0.022 |
| Change in VEGF-D | 46 | 1.33 | 0.42–4.22 | 0.632 | |||
N= 46 subjects. Subjects were randomly selected from the CAV cohort who met or did not meet the endpoint (2:1 ratio).