. Author manuscript; available in PMC: 2017 Mar 29.

Published in final edited form as: Semin Immunol. 2016 Mar 29;27(6):369–378. doi: 10.1016/j.smim.2016.03.017

Table 1.

Comparison of YS-EMP-derived tissue macrophages and HSC-derived myeloid cells/macrophages

	Myb-independent tissue macrophages	HSC-derived myeloid cells/macrophages
Progenitor	erythromyeloid progenitor (EMP)	hematopoietic stem cells (HSC)
Progenitor surface phenotype	CD45^low Kit⁺ AA4.1⁺ CD16/32⁺ CD41⁺ Sca1^neg	LSK-SLAM (Lin^neg Sca1⁺ Kit⁺CD150⁺CD48⁻)
Hematopoietic niche	Yolk sac/fetal liver	AGM region and large embryonic arteries/ fetal liver; Bone marrow
Macrophage Surface markers	F4/80^high CD11b^low	F4/80^low CD11b^high
Common markers (gene expression pattern)	Csf1r, CX₃CR1	CCR2, Flt3
Maintenance in the adult	Local self-renewal, proliferation, depending on Csf1r-signaling (Il-34 or Csf1)	Replacement by circulating HSC-derived progenitors
Transcription factors for differentiation	Pu.1, Runx1	Pu.1, Runx1, c-Myb, Gata-2 (?)
Transcription factor for tissue adaption	Different factors depending on tissue (see table 2)	Not described yet
Physiological function within tissues	Tissue homeostasis, removal of apoptotic cells and secretion of growth factors, stem cell survival	Not described yet
Function under challenge within tissues	Tissue inflammation, phagocytosis of dead cells and pathogens, antigen presentation Tissue repair, phagocytosis	Tissue inflammation, secretion of pro-inflammatory cytokines, antigen presentation