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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Expert Opin Ther Pat. 2016;26(3):297–308. doi: 10.1517/13543776.2016.1153065

Table 4.

Substrate specificity of 3C and 3CL proteases of viruses in the picornavirus-like supercluster

Viral 3C or 3CL protease P5 P4 P3 P2 P1 P1’ P2’
EV71 E A V/L/T L/F Q G P
CVA16 E A L F Q G P
SARS-CoV S A V/T/K L Q A/S G
NV D/E F/Y H/Q/E L Q G P