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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: AIDS. 2016 Jun 1;30(9):1327–1339. doi: 10.1097/QAD.0000000000001092

Table 3.

Multivariable models for baseline biomarkers significantly associated with lower pulmonary function in HIV-infected participants during follow-up

Post-bronchodilator FEV1 percent-predicted beta (95% CI) p-value
ET-1* −0.20 (−0.30 – −0.11) <0.001
Pack-years smoked** −0.01 (−0.03 – −0.002) 0.02
Time (per year) −0.03 (−0.04 – −0.02) <0.001
Interaction term between ET-1 and time ---- 0.16
DLCO percent-predicted beta (95% CI) p-value
sCD163* −0.08 (−0.16 – −0.001) 0.047
Pack-years smoked** −0.02 (−0.03 – −0.005) 0.005
Time (per year) 0.02 (0.006 – 0.04) 0.005
Interaction term between sCD163 and time ---- 0.90
DLCO percent-predicted beta (95% CI) p-value
ET-1* −0.10 (−0.20 – −0.006) 0.04
Pack-years smoked** −0.01 (−0.03 – −0.001) 0.04
Time (per year) 0.02 (0.007 – 0.04) 0.005
Interaction term between ET-1 and time ---- 0.30

CI: confidence interval, DLCO: diffusing capacity for carbon monoxide, ET-1: endothelin-1, FEV1: forced expiratory volume in one second

*

Log transformation

**

Square-root transformation