Table 5.

Blood Clotting Markers

		Placebo			ACE
Test (Unit)	Reference ranges	Week 0	Week 2	P*	Week 0	Week 2	P*	P**
aPTT (sec)	22.7–35.8	25.35 ± 0.78	25.43 ± 0.83	.896	25.30 ± 0.59	25.78 ± 0.63	.441	.429
Thrombin time (sec)	17.2–23	17.87 ± 0.16	18.57 ± 0.27	.026	17.76 ± 0.12	18.33 ± 0.24	.040	.695
Fibrinogen activity (mg/dL)	170–410	311.17 ± 27.46	294.75 ± 22.53	.127	330.75 ± 16.76	343.67 ± 24.02	.364	.257

The average ± standard deviation is shown.

^*P-values shown for the change from baseline to 2 weeks within each group.

^**P-values shown for the difference in the 2-week change between the two groups.

aPTT, activated partial thromboplastin time.