Heat map illustrating cluster of transcripts that were sensitive to PVS supplementation. PVS-sensitive transcripts were subjected to hierarchical clustering. (A) A total of 175 annotated probe sets were differentially (P < .05) regulated following 8 weeks of oral PVS supplementation compared with baseline visits. (B) Pathway analysis revealed an ECM-related cluster of probe sets that was significantly upregulated following 8 weeks of supplementation compared with corresponding baseline visit. COL1A1, collagen type I alpha1; COL1A2, collagen type I alpha 2; COL5A2, collagen type V alpha 2; COL6A3, collagen type VI alpha 3; COL14A1, collagen type XIV alpha 1, DCN, decorin; ECM, extracellular matrix; ELN, elastin; FBN1, fibrillin 1; FN1, fibronectin 1; MYOF, myoferlin; TNXB, tenascin XB; V1, baseline visit; V2, 8 weeks of oral PVS supplementation.