Table 5.
Genes Downregulated in Skeletal Muscles Following Oral PVS Supplementation
| Transcript cluster ID | Gene symbol | Gene description | Fold change | P |
|---|---|---|---|---|
| 19534964 | SNAR-G2 | Small ILF3/NF90-associated RNA G2 | −1.27 | .0023 |
| 19140074 | MIR4792 | MicroRNA 4792 | −1.24 | .0065 |
| 18729405 | SIX2 | SIX homeobox 2 | −1.23 | .0057 |
| 18928262 | KLF13 | Kruppel-like factor 13 | −1.22 | .0035 |
| 19195587 | MIR4635 | MicroRNA 4635 | −1.21 | .0008 |
| 18820492 | VGF | VGF nerve growth factor inducible | −1.21 | .0095 |
| 19160216 | DRD5 | dopamine receptor D5 | −1.21 | .0003 |
| 18949268 | GCSH | Glycine cleavage system protein H (amino methyl carrier) | −1.20 | .0076 |
| 19113156 | MIR3132 | MicroRNA 3132 | −1.20 | .0006 |
| 18939902 | CLDN9 | Claudin 9 | −1.20 | .0035 |
| 18999582 | IGLV2-33 | Immunoglobulin lambda variable 2-33 (nonfunctional) | −1.19 | .0054 |
| 18885915 | MIR210HG | MIR210 host gene (nonprotein coding) | −1.19 | .0000 |
| 18739218 | IGKV1-37 | Immunoglobulin kappa variable 1–37 (nonfunctional) | −1.18 | .0024 |
| 19043031 | LOC100287934 | LOC100287934 | −1.17 | .0072 |
| 19499270 | MIR4734 | MicroRNA 4734 | −1.17 | .0037 |
| 19222951 | LINC00602 | Long intergenic nonprotein coding RNA 602 | −1.16 | .0008 |
| 18979687 | TICAM1 | Toll-like receptor adaptor molecule 1 | −1.16 | .0031 |
| 19570418 | RN5S497 | RNA, 5S ribosomal 497 | −1.15 | .0027 |
| 18800247 | IER3 | Immediate early response 3 | −1.15 | .0021 |
| 19524368 | SPACA4 | Sperm acrosome associated 4 | −1.14 | .0034 |
| 18889853 | YIF1A | Yip1 interacting factor homolog A (Saccharomyces cerevisiae) | −1.14 | .0003 |
Data presented indicate fold change in expression of PVS-sensitive genes following 8 weeks of oral PVS supplementation compared with corresponding baseline visits. Transcripts cluster ID, Affymetrix probe identifications. Data correspond to Figure 1A, cluster b (P < .05; FDR <5%).