FIG. 7.

Lack of HO-1 augments renal fibrosis and macrophage infiltration following UUO. (A, B) Representative UUO and sham control kidneys of HO-1^+/+ and HO-1^−/− mice, 7 days following obstruction. (A) Masson's trichrome stain of renal cortex and corticomedullary junction. Scale bar = 400 μm. (B) Immunohistochemistry for F4/80⁺ cells in the renal cortex. Scale bar = 100 μm. (C) Representative Western blot analysis for Fn in kidney lysates. (D) Densitometry for Fn normalized to β-actin. *p < 0.05 versus all other groups. Reproduced with permission from Kie et al. (67). CL, contralateral, uninjured kidney; Fn, fibronectin; UUO, unilateral ureteral obstruction. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars