Table 4.

Univariate and multivariable analysis looking for factors related with time-to-stent-related event

Time-to-SRE		Univariate analysis (Fine-Gray regression)		Multivariable analysis (Fine-Gray regression)
		HR (95%CI)	P-value	HR (95%CI)	P-value
Primary	BTC	Ref		X
	Pancreas	0.8 (0.4-1.5)	0.407
Stage	Locally advanced	Ref		X
	Metastatic	1.4 (0.8-2.6)	0.251
ECOG-PS	0/1	Ref		X
	≥ 2	0.8 (0.4-1.5)	0.435
Comorbidities	None	Ref		Ref
	Mild	0.8 (0.4-1.7)	0.605	1.1 (0.5-2.2)	0.844
	Moderate	0.9 (0.4-1.9)	0.734	1.1 (0.5-2.2)	0.986
	Severe	3.6 × 10-8 (1.2 × 10-8-1.1 × 10-7)	< 0.001	9.4 × 10-7 (2.9 × 10-7-3.1 × 10-6)	< 0.001
Number of stents/biliary interventions at baseline	1	Ref		Ref
	≥ 2	2.5 (1.4-4.6)	0.003	2.3 (1.2-4.44)	0.010
Type of the most recent stent	Metal	Ref		X
	Plastic	2.1 (0.7-6.5)	0.182

Fine-Gray Regression; competing event: Death. BTC: Biliary tract cancer; ECOG-PS: ECOG performance status.