Table S5.
Estimates from the quadratic regression from Lande and Arnold (16) of rLRS on all of the polygenic scores of the different phenotypes, all of the squared polygenic scores, and all their interactions
| Score | Females | Males |
| Score of BMI | 0.003 (0.011) | 0.012 (0.013) |
| Score of EA | −0.035*** (0.011) | −0.029** (0.013) |
| Score of GLU | 0.010 (0.010) | −0.012 (0.013) |
| Score of HGT | −0.008 (0.014) | 0.004 (0.018) |
| Score of SCZ | −0.001 (0.011) | 0.006 (0.014) |
| Score of TC | −0.013 (0.011) | −0.004 (0.013) |
| Score of AAM | 0.022** (0.011) | — |
| Squared score of BMI | −0.006 (0.008) | −0.001 (0.010) |
| Squared score of EA | −0.012 (0.008) | −0.004 (0.009) |
| Squared score of GLU | −0.007 (0.007) | −0.002 (0.009) |
| Squared score of HGT | −0.009 (0.007) | 0.000 (0.009) |
| Squared score of SCZ | 0.010 (0.007) | 0.022** (0.009) |
| Squared score of TC | −0.007 (0.007) | 0.000 (0.009) |
| Squared score of AAM | −0.004 (0.008) | — |
| Score of BMI × score of EA | 0.005 (0.011) | 0.004 (0.013) |
| Score of BMI × score of GLU | 0.002 (0.011) | −0.011 (0.013) |
| Score of BMI × score of HGT | −0.008 (0.012) | −0.015 (0.013) |
| Score of BMI × score of SCZ | 0.017 (0.011) | 0.015 (0.013) |
| Score of BMI × score of TC | 0.009 (0.011) | 0.016 (0.014) |
| Score of BMI × score of AAM | −0.012 (0.011) | — |
| Score of EA × score of GLU | −0.006 (0.011) | 0.017 (0.012) |
| Score of EA × score of HGT | −0.003 (0.011) | 0.001 (0.013) |
| Score of EA × score of SCZ | 0.001 (0.011) | −0.032** (0.013) |
| Score of EA × score of TC | −0.010 (0.011) | 0.000 (0.013) |
| Score of EA × score of AAM | 0.003 (0.011) | — |
| Score of GLU × score of HGT | −0.020* (0.011) | −0.002 (0.013) |
| Score of GLU × score of SCZ | −0.008 (0.011) | 0.008 (0.013) |
| Score of GLU × score of TC | −0.007 (0.010) | 0.013 (0.013) |
| Score of GLU × score of AAM | −0.015 (0.011) | — |
| Score of HGT × score of SCZ | 0.004 (0.011) | 0.022 (0.014) |
| Score of HGT × score of TC | 0.000 (0.011) | −0.010 (0.013) |
| Score of HGT × score of AAM | 0.003 (0.012) | — |
| Score of SCZ × score of TC | −0.028*** (0.010) | −0.004 (0.013) |
| Score of SCZ × score of AAM | −0.019* (0.011) | — |
| Score of TC × score of AAM | 0.002 (0.011) | — |
| N | 3,416 | 2,571 |
This table shows estimates (and their SEs, in parentheses) from the quadratic regression from Lande and Arnold (16) of rLRS on all of the polygenic scores of the different phenotypes, all of the squared polygenic scores, and all their interactions, for the study sample. (I thus treat the scores themselves—as opposed to the phenotypes, as is usual—as the characters of interest in Lande and Arnold’s quadratic framework.) The estimates for females come from one single regression, and the estimates for males come from another single regression. Each regression included birth year dummies, HRS-defined cohort dummies, and the top 20 principal components of the genetic relatedness matrix. (*P < 0.10; **P < 0.05; ***P < 0.01.)