Fig. 1.
Rapid antidepressant-like action of LAC oral dose. (A) Experimental procedure implemented to test LAC efficacy at a low oral dose (Supporting Information) in endogenously depressed FSL rats with behavioral outcome at FST on day 6. (B) Six days of oral administration with LAC exerts clear-cut antidepressant-like effects as suggested by the rapidly decreased immobility of FSL. F1,25 = 8.54, P < 0.05 (treatment); F1,25 = 15.56, P < 0.001 (phenotype). (C) Representative FST tracing for mobility time. Bars represent mean + SEM, *significant comparisons with veh-FRL, #significant comparisons with veh-FSL. **P < 0.01, #P < 0.05.