Fig. S2.

PPI network emanating from PKA. Following phosphoproteomic analyses using LC-MS/MS, we generated a static PPI network of the confident set of PKA interacting proteins. We neglected applied pharmacological applications for the construction of the macromolecular PKA PPI network. Dark lines indicate known interactions. Triangles indicate identified phosphopeptides; circles indicate identified peptides; squares indicate identified peptides and phosphopeptides from the same protein or protein isoform. With italic lettering we indicate proteins with nucleotide binding capacity, including ATP, cAMP, cGMP, FAD, NAD, and GTP binding.