[Table/Fig-2]:

Summary of the results.

Study and year	Title	Sample size	Patient characteristic	Duration of treatment	Study design	Dose	Blinding	Results/ summary
1. Turkoglu O et al., in 2014 [2]	The effect of adjunctive chlorhexidine mouthrinse on GCF MMP-8 and TIMP-1 levels in gingivitis: a randomized placebo-controlled study	50	50 individuals aged 18–45 years of age, male or female patients with gingivitis associated with dental plaque, clinical attachment level <3 mm, a minimum of 20 teeth	28 days	2 groups:- Experimental:- (chlorhexidine mouthrinse) Control:- (placebo mouthrinse)	10 ml mouth rinse for 1 minute twice daily, 30 minutes after tooth brushing	Double blind	1. CHX group showed lower PI values than the placebo group at 4 weeks (p < 0.05) and the reductions in the PI from baseline were significantly greater in the CHX group (p < 0.05).
2. Jhingta P et al., in 2013 [3]	Effect of hydrogen peroxide mouthwash as an adjunct to chlorhexidine on stains and plaque	105 subjects	55 (57.75%) were females and 50 (52.5%) were males. The subjects included BDS and dental hygienist students of the college and the patients visiting the outpatient department of Periodontics	21 days (1 week, 2 week, 3 week)	3 treatment groups; each group comprises 35 subjects. Group I -0.2% CHX (Hexidine®) twice daily (60s) for 3 weeks after brushing. Group II -0.2% CHX (60 s) followed by 1.5% H2O2 (60 s) twice daily for 3 weeks after brushing. Group III - 1.5% H2O2 (60 s) followed by 0.2% CHX (60 seconds) twice daily for 3 weeks after brushing.	Rinsing twice daily after toothbrushing for 1 minute	Unclear	In all the three groups, there was a reduction in mean plaque score at the end of 2 weeks in comparison with scores at the end of 1 week and was significant in group I. At the end of 3 weeks also, there was further reduction in plaque scores in comparison with the scores at 2 weeks in all three groups. The reduction was significant in group I and group III. After the end of 3rd week, the mean stain area was significantly more than the scores at the end of 2nd week in group I and group II. There was less amount of plaque formed in group II than group I after the end of 1st, 2nd, and 3rd week and the difference was highly significant (p values: 000, 0.000, and 0.000, respectively. In comparison to group I, there was significantly less amount of plaque formed in group III after the end of first (p-value, 0.000) and second week (0.017). After the end of 3 weeks also, the plaque scores were less in group III than group I but it was not significant (p-value, 0.104).
3. Albert-Kiszely A et al., in 2007 [7]	Comparison of the effects of cetylpyridinium chloride with an essential oil mouth rinse on dental plaque and gingivitis – a six-month randomized controlled clinical trial.	151	151 subjects aged 18-65 yrs with good general health and minimum of 18 natural teeth(40 men and 111 women)	90 days and 180 days	2 groups:- Test group- cetylpyridinium mouthrinse Control group- essential oil mouthrinse.	rinse twice daily with 20 ml of rinse for 30 s after 1 min. of regular toothbrushing.	Double blind	There were no significant differences between the experimental and the positive control mouthrinse treatment groups for overall gingivitis status and plaque accumulation. A significant greater reduction in bleeding sites was observed for the CPC rinse versus the EO rinse. (p<0.05)
4. Arora V et al., in 2014 [15]	Efficacy of Dental Floss and Chlorhexidine Mouth rinse as an adjunct to Toothbrushing in removing Plaque and Gingival Inflammation – A Three Way Cross Over Trial	45	Forty five dental students in the age group of 19-25yr.	21 days	3 groups:- (n=15). Group A– Toothbrushing with Dental floss (TB+DF), Group B– Toothbrushing with 0.12% Chlorhexidine Gluconate Mouthrinse (TB+CHX-MR) and Group C– Toothbrushing alone (TB Alone)	15 ml mouth rinse for 30 seconds twice daily, 30 minutes after tooth brushing	Double blind	Group B showed more reduction in plaque and gingival scores in comparison to Group A and Group C which was found to be statistically significant (p<0.001). While comparing between group A and group C at second and third follow-up, no significant difference were observed.
5. Harini PM. Anegundi RT. In 2010 [20]	Efficacy of a probiotic and chlorhexidine mouth rinses: A short-term clinical study	45	45 children aged 6-8 years.	14 days	3 groups [Group A, B, and C] with 15 children in each group as follows: Group A: Control group (mint water) Group B: Probiotic group Group C: Chlorhexidine group	Rinse once daily about 30 min after tooth brushing with 15 mL of the solution (1:1 dilution for chlorhexidine) for 60 s	Double blind	There was a significant decrease in the mean PI and mean GI scores of Probiotic and Chlorhexidine groups when compared with that of the Control group. No significant differences in the mean plaque accumulations between the Probiotic and Chlorhexidine groups but there was significant difference in GI between probiotic nad chlorhexidine group (probiotic being better than chlorhexidine mean=0.2300 and 0.6805 respectively)
6. Najafi M H et al., in 2012 [22]	Comparative study of 0.2% and 0.12% digluconate chlorhexidine mouth rinses on the level of dental staining and gingival indices	60	60 patients aged 17–56 years having gingivitis and bleeding on probing but no attachment loss or bone loss.	14 days	3 groups: Experimental group- 0.2% chlorhexidine and 0.12% chlorhexidine mouthrinse Control group: Placebo	Rinsing twice daily after toothbrushing	Double blinding	Significant reduction of plaque and gingival bleeding in chlorhexidine group than placebo group. Gingival bleeding was significantly reduced in 0.2% chlorhexidine in comparison to 0.12% chlorhexidine. Dental staining was significantly more in 0.2% chlorhexidine in comparison to 0.12% chlorhexidine and placebo(more in comparison group than placebo).
7. Mythri H et al., in 2011 [23]	The efficacy of antiseptic mouth rinses in comparison with dental floss in controlling interproximal gingivitis	160	160 subjects with four index age groups 12, 15, 35-44 and 65-74(40 in each group) were included.	3 and 6 month	4 study groups were: Group I – Brushing only (control) Group II – Brushing and flossing (Pick-n-floss dental floss holder) Group III – Brushing and rinsing with essential oil mouth rinse (Cool mint Listerine, Pfizer Company Ltd, Mumbai, India) Group IV– Brushing and rinsing with Chlorhexidine mouth rinse (0.2% Chlorhexidine gluconate)	20 ml mouth rinse for 30 seconds twice daily, 30 minutes after tooth brushing	Single blind	group I and group II showed reduction in PI, MGI and BI from baseline to 3- and 6-month evaluation, not statistically significant in comparison to group III and group IV which showed statistically significant reduction.(p<0.05) Comparisons between group III and group IV showed group IV to be more effective than group III.
8. Sharma N et al., in 2004 [24]	Adjunctive benefit of an essential oil– containing mouthrinse in reducing plaque and gingivitis in patients who brush and floss regularly A six-month study	246	246 patients with mild to moderate gingivitis.	6 month	3 treatment groups: group I:- brushing and rinsing with a control mouthrinse, Group II:-brushing, flossing and rinsing with a control mouthrinse, Group III:-brushing, flossing and rinsing with an EO–containing mouthrinse.	brush twice daily with an ADA-Accepted toothbrush and dentifrice as well as to rinse twice daily with a 5 percent hydroalcohol control mouthrinse.	Investiga-tor blind	The subjects using the BFEO regimen had statistically and clinically significant lower mean Modified Gingival Index, or MGI, scores and Plaque Index, or PI, scores than did subjects in the BC and BFC group . Subjects in the BFC group had statistically significantly lower mean MGI and PI scores than did subjects in the BC group. (p<0.001)
9. Pilloni A et al., in 2010 [28]	Perceived and measurable performance of daily brushing and rinsing with an essential oil mouthrinse	766	766 generally healthy Italian subjects aged 19-66 years, with mild to moderate levels of gingivitis, no pockets of more than 4 mm, and at least 20 scorable teeth.	3 month	-	Brushed twice daily, immediately followed by rinsing for 30 sec with 20 ml of an essential oil mouthrinse (Listerine®).	Unclear	There was statistically significant reduction in plaque(51.9% reduction) and gingivitis(45.7% reduction).(p<0.001)
10. Pedrazzi V et al., in 2015 [29]	Herbal Mouthwash Containing Extracts of Baccharis dracunculfolia Agent for the Control of Biofilm: Clinical Evaluation in Humans	12	12 healthy individuals were taken	7 days	4 groups: Experimental:- 1. Plax 2. B. dracunculifolia extract and essential oil 3. Listerine Control group	Rinsing after toothbrushing for 1 minute	Triple blinding	Significant reduction of plaque in experimental group in comparison to control group. Test formulation with active B. dracunculifolia reduced the rate of plaque (biofilm) after one weekof use, in the same level as chloride triclosan, Gantrez, and essential oils. (p<0.001)