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. 2016 Mar 4;108(7):djw003. doi: 10.1093/jnci/djw003

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — A Bayesian multivariable probabilistic sensitivity analysis found imatinib-first to be cost-effective compared with physician’s choice in 99.7% of 10 000 Monte Carlo simulations. The circular line indicates the 95% confidence interval of incremental cost-effectiveness ratios (ICERs) among simulations, and the dotted diagonal line indicates the willingness-to-pay threshold, which has a slope of $100 000/QALY. Simulations appearing below this line favor the imatinib-first strategy as cost-effective. Incremental effectiveness along the x-axis is measured in units of quality-adjusted life-years (QALYs). Incremental cost along the y-axis is measured in units of US dollars ($), adjusted for inflation to 2013. The ICER of each simulation is calculated as a ratio of incremental cost over incremental effectiveness ($/QALY).