Figure 6.

Structural comparison of several phenyltetrazole-containing influenza endonuclease inhibitors. Left: Crystal structure of Sagong-11 (PDB code 4W9S). Middle: Crystal structure of a derivative of Parhi-6 (PDB code 4M4Q). Right: Docking analysis of 71 (PDB code 4M4Q). Crystal structures of phenyltetrazole-containing inhibitors show the binding orientation of the phenyltetrazole moiety to be essentially conserved. Docking analysis of 71 predicts a very similar binding mode for this moiety to that observed in crystallographically validated inhibitors.