Table 3. Biodistribution of ¹¹¹In-CP04 in SCID mice bearing double A431-CCK2R(±) xenografts.

	%ID/g tissue, mean ± sd (n = 4)
	[111In]CP04
Organs	1 h	4 h	4 h + gelo	4 h ref.	24 h
Blood	0.55 ± 0.17	0.02 ± 0.01	0.02 ± 0.01	0.04 ± 0.02	0.00 ± 0.00
Liver	0.38 ± 0.12	0.11 ± 0.01	0.17 ± 0.14	0.12 ± 0.02	0.01 ± 0.01
Heart	0.24 ± 0.08	0.02 ± 0.01	0.03 ± 0.01	0.03 ± 0.01	0.02 ± 0.00
Kidneys	5.53 ± 0.78	5.55 ± 0.94	1.69 ± 0.15***	6.52 ± 0.63ns	3.29 ± 0.56
Stomach	2.60 ± 0.48	2.09 ± 0.32	2.15 ± 0.24ns	1.63 ± 0.20	1.58 ± 0.15
Intestines	0.36 ± 0.13	0.22 ± 0.08	0.39 ± 0.13	0.29 ± 0.18	0.10 ± 0.04
Spleen	0.18 ± 0.04	0.04 ± 0.02	0.07 ± 0.01	0.06 ± 0.02	0.05 ± 0.01
Muscle	0.14 ± 0.05	0.03 ± 0.02	0.03 ± 0.01	0.02 ± 0.01	0.01 ± 0.01
Lung	0.47 ± 0.13	0.04 ± 0.01	0.05 ± 0.03	0.04 ± 0.01	0.03 ± 0.01
Femur	0.96 ± 0.46	0.30 ± 0.22	0.27 ± 0.02	0.39 ± 0.08	0.24 ± 0.09
Pancreas	0.23 ± 0.08	0.06 ± 0.01	0.07 ± 0.01	0.07 ± 0.01	0.05 ± 0.01
Tumour(+)	12.60 ± 1.73	9.24 ± 1.35	7.99 ± 2.45ns	8.49 ± 0.39ns	4.98 ± 0.56
Tumour(–)	1.07 ± 0.29+++	0.19 ± 0.05+++	0.22 ± 0.03+++	0.14 ± 0.02+++	0.10 ± 0.02+++

Statistical analysis was performed using the Student’s t-test with P values indicating very significant (***/+++P < 0.001) and not significant (ns, P > 0.05) difference (+) between Tumour(+) (A431-CCK2R(+)) and Tumour(–) (A431-CCK2R(–)) and (*) between the 4 h and 4 h + gelofusine-treated mice. The values in column 4 h-ref. correspond to a separate group of mice injected with ¹¹¹In-CP04 obtained by “wet-labelling”; no significant differences were observed between this group and the 4-h group injected with ¹¹¹In-CP04 prepared by kit reconstitution.