Table 2.
Effects of different types of exercise on MMPs
| Study | Samples | Training type | Length of study | Tissue | Outcome | P-value |
|---|---|---|---|---|---|---|
| Souza et al62 | Wistar rats (N=32; C=8, C-OB=8, EG=8, EG-OB=8) | RT | 12 weeks | Skeletal muscle | MMP-2 ↑ | P<0.05 |
| Leite et al59 | Wistar rats (N=32; C=8, C-OB=8, EG=8, EG-OB=8) | RT | 12 weeks | Left ventricle | MMP-2 ↑ | P<0.01 |
| Nascimento et al63 | Obese elderly women (N=10) | RT | Acute | Plasma | MMP-2 ↓ MMP-9 ↓ |
P<0.05 |
| Rullman et al60 | Healthy males (N=10) | RT | 5 weeks | Skeletal muscle | MMP-2 ↑ MMP-9 ↑ |
P<0.001 P<0.05 |
| Scheede-Bergdahl et al61 | Type 2 diabetic males (N=22; C=10, T2D=12) | RT | 8 weeks | Skeletal muscle | MMP-2 ↑ | P<0.05 |
| Donley et al69 | MetS females (C=22, MetS=22) | AT | 8 weeks | Plasma | MMP-1 ↓ | P<0.05 |
| Rullman et al68 | Healthy males (N=10) | AT | Acute | Skeletal muscle | MMP-2 ↔ MMP-9 ↑ |
P<0.05 P<0.05 |
| Shon et al65 | ApoE-/- mice (N=68; C=15, C-OB=26, EG=9, EG-OB=18) | AT | 10 weeks | Atheroma | MMP-2 ↓ MMP-9 ↓ |
P<0.05 P<0.05 |
| Posa et al51 | Wistar rats (N=70; C=35, EG=35) | AT | 6 weeks | Plasma | MMP-2 ↓ | P<0.001 |
| Kwak et al64 | Aging rat model (N=40; C=10, EG=10, O=10, O-EG=10) | AT | 12 weeks | Left ventricle | MMP-1 ↓ MMP-2 ↓ MMP-9 ↔ |
P<0.05 P<0.05 NS |
| De Aro et al66 | Wistar rats (N=77; C=11, 1d1h=11, 1d3h=11, 3d1h=11, 3d3h=11, 6d1h=11, 6d3h=11) | AT | 1, 3, 6 days | Calcaneal tendon | MMP-2 ↔, ↔, ↑ MMP-9 ↔, ↔, ↔ |
P<0.05 NS |
| Nishijima et al67 | Wistar rats (N=4, EG=16) | AT | 1 week | Hippocampus | MMP-2 ↔ MMP-9 |
NS P<0.05 |
Note: “↑” indicates an increased level; “↓” indicates a decreased level; and “↔” indicates no change.
Abbreviations: ApoE−/−, apolipoprotein E knockout; AT, aerobic exercise; C, control; C-OB, control obese; d, days, EG, exercise group; EG-OB, obese exercise group; h, hours; MetS, metabolic syndrome; MMP, matrix metalloproteinase; NS, not shown; O, old; O-EG, old exercise group; RT, resistance training; T2D, type 2 diabetes.