Fig. 4.

Molecular phylogenetic analysis of GNATs. Phylogenetic tree for GNAT sequences shows the three conventional gnathostome clades, GNAT1, GNAT2, GNAT3, together with a potentially distinct group, denoted GNATX, detected only in agnathan species. Analysis details (see Materials and Methods for explanation): Maximum likelihood; 1000 replicates; 35 sequences; all 374 residues used; JTT model; nearest neighbor interchange, with branch swap filter set to very strong. The outgroup comprises the three human GNAI members together with similar sequences from two species of Ciona.