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. Author manuscript; available in PMC: 2016 Jul 18.
Published in final edited form as: Cancer Res. 2011 Jan 15;71(2):463–472. doi: 10.1158/0008-5472.CAN-10-1252

Figure 2. (A) Characterization of the CHK2 activation pathway and p53 status in a panel of human tumor cell lines.

Figure 2

Cells were irradiated (5 Gy) and samples taken 4 hours post treatment. Similar results were obtained in a repeat experiment. (B) Effect of CCT241533 on etoposide induced biomarker changes. HT-29 or HeLa cells were pre-incubated with different concentrations of CCT241533 for 1 hour, followed by the addition of 50 μM etoposide or DMSO control and incubated for a further 5 hours. Similar results were obtained in repeat experiments.