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. 2016 Jul 18;11(7):e0159508. doi: 10.1371/journal.pone.0159508

Fig 10. Regulation of M8 activity by reversible phosphorylation.

Fig 10

(A) In the ‘cis’-inhibited state, the CtD interacts with the HLH and/or Orange domains thereby blocking M8 repression of Ato. Phosphorylation by CK2 and MAPK serves as a conformational switch that converts M8 into an Ato repressor, whereas PP2A mediates inactivation. (B) Model for spatial and/or temporal regulation of M8 activity at stage-2/3 of the MF. EGFR/MAPK signaling ensures that M8 activation does not occur until stage-2/3 of the MF, thereby allowing ato-auto-activation to raise Ato levels to a threshold sufficient for the R8 fate. In this case, the phosphatase PP2A targets M8 to control either the ‘amplitude’ or ‘duration’ of active M8.