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. 2016 Jul 18;11(7):e0159447. doi: 10.1371/journal.pone.0159447

Table 1. Results of the meta-analysis on prognostic significance of NLR in CRLM.

Overall Survival Recurrence Free Survival
No. studies No. patients HR 95% CI I2,% P value for heterogeneity No. studies No. patients HR 95% CI I2,% P value for heterogeneity
Overall 7 1491 2.17 1.82–2.58 0 0.66 6 1093 1.96 1.64–2.35 45.20 0.10
Treatment methods
Surgical resection 5 1309 2.08 1.73–2.49 0 0.74 4 903 1.89 1.34–2.66 58.60 0.07
Non-surgical treatment 2 182 3.11 1.83–5.29 0 0.71 2 190 2.33 1.37–3.95 29.90 0.23
Sample size
≥100 5 1309 2.08 1.73–2.49 0 0.74 3 286 1.79 1.24–2.59 68.20 0.04
<100 2 182 3.11 1.83–5.29 0 0.71 3 807 2.48 1.55–3.98 0 0.42
NLR cutoff
= 5 6 1322 2.17 1.81–2.60 0 0.53 4 826 2.27 1.84–2.80 0 0.69
= 2.5 1 - - - - - 2 267 1.30 0.91–1.85 0 0.46

NLR: neutrophil-lymphocyte ratio; HR: hazard ratio; CI: confidence interval.