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. 2016 Jul 18;11(7):e0159414. doi: 10.1371/journal.pone.0159414

Fig 7. Diagram illustrating the proposed mechanisms of chronic iron overload on cardiac dysfunction and the effects of all pharmacological interventions on cardiac dysfunctions caused by chronic iron overload.

Fig 7

Dashed arrows indicate the effects of either DFO, DFP, DFX or NAC treatment; solid arrows indicate the effects of combined DFP plus NAC treatment. DFO = deferoxamine; DFP = deferiprone; DFX = deferasirox; NAC = N-acetyl cysteine; NTBI = non-transferrin bound iron; MDA = malondialdehyde.