Table 2. The effects of the pharmacological interventions on hemodynamic parameters in iron-overloaded rats.
| Hemodynamic parameters | Control | HFeV | HFeDFO | HFeDFP | HFeDFX | HFeNAC | HFeDFP+NAC |
|---|---|---|---|---|---|---|---|
| Heart rate (beats / min) | 253±2 | 233±9 | 240±11 | 237±7 | 255±18 | 235±17 | 253±12 |
| LVESP (mmHg) | 141±5 | 110±5* | 126±4*,† | 124±5*,† | 124±6*,† | 125±3*,† | 132±1† |
| LVEDP (mmHg) | 24±1 | 20±3 | 23±2 | 25±2 | 22±3 | 26±3 | 25±2 |
| Pmax (mmHg) | 144±4 | 115±4* | 129±5*,† | 128±5*,† | 129±6*,† | 128±3*,† | 135±2† |
| Pmin (mmHg) | 20±0.2 | 15±3 | 17±2 | 21±2 | 18±3 | 21±3 | 21±1 |
| Cardiac output (mL/min) | 132±4 | 91±4* | 111±3*,† | 111±6*,† | 112±8*,† | 110±5*,† | 118±8† |
| Stroke volume (μL) | 517±13 | 396±10* | 434±9*,† | 447±12*,† | 434±13*,† | 436±4*,† | 459±7*,† |
LVESP, LVEDP, left-ventricular end-systolic and end-diastolic pressure; Pmax, Pmin, maximum and minimum pressure.
*P < 0.05 vs. control,
†P < 0.05 vs. HFe.