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. 2016 Jul 18;14(7):e1002516. doi: 10.1371/journal.pbio.1002516

Fig 8. MCU overexpression restores presynaptic release properties in LKB1-deficient neurons.

Fig 8

(A–D) MCU overexpression by lentiviral infection restored mEPSC frequency in LKB1-deficient cortical neurons. Values were normalized by the average of control from each experiment. n = 1,108 from 27 neurons for control, 1,030 events from 26 neurons for LKB1-deletion, 1,065 events from 21 neurons for LKB1-deletion+MCU. *** p < 0.001, Mann-Whitney test. (E–J) Colored representative traces show the average of nine traces (grey) of evoked EPSC (10 AP at 10 Hz). Increased delayed release observed LKB1-deficient neurons was partially rescued by MCU overexpression (E–H). Peak amplitude of first eEPSC was not rescued by MCU overexpression. (I). MCU overexpression restored short-term depression in LKB1-deleted neurons back to control levels (J). Graph represents normalized EPSC amplitude. n = 140 responses from 20 neurons for control, 169 responses from 17 neurons for LKB1-deletion, 160 responses from 17 neurons for LKB1-deletion+MCU. ** p < 0.01, **** p < 0.0001. Mann-Whitney test. Individual values are available in S1 Data.