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. 2016 Jul 18;12(7):e1006190. doi: 10.1371/journal.pgen.1006190

Fig 2. Loss of MSH6 reduces the frequency of paternally and maternally transmitted expansions.

Fig 2

The % of alleles with the indicated number of repeats added or lost seen on transmission of a PM allele with ~160 repeats from Msh6+/+, Msh6+/- and Msh6-/- parents. A total of 44 Msh6+/+, 70 Msh6+/- and 41 Msh6-/- paternal transmissions and 53 Msh6+/+, 65 Msh6+/- and 43 Msh6-/- maternal transmissions were examined. Differences in frequency of expansions, contractions and unchanged alleles were compared for each pair of genotypes using Fisher’s exact test in which each allele class was considered in relation to the sum of the other two allele size classes. The allele classes that are significantly different from Msh6+/+ animals are marked with asterisks (*, p<0.05; **, p<0.01; ***, p<0.001); frequencies were also compared across all 3 genotypes with exact Jonckheere-Terpstra tests (p<0.001 for each sex).