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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Diabetes Obes Metab. 2015 Dec 23;18(2):142–151. doi: 10.1111/dom.12590

Figure. 1. Retinoic Acid Receptor β (RARβ) Agonists Diminish Body Weight Increases, Glucose Intolerance, and Insulin Resistance in Genetic Models of Diabetes.

Figure. 1

A) Body weights of wild type (wt) chow-fed C57/Bl6, and genetically obese ob/ob and db/db male mice that were fed either a standard chow diet (con, 13% Kcal/fat), or a con diet plus the RARβ2 agonist AC261066 (AC261) in their drinking water for 8 weeks. (Wt Con, n=4), (Wt Con + AC261, n=3), (ob/ob, con, n=3), (ob/ob, con + AC261, n=3), (db/db, con, n=3), (db/db, con + AC261, n=3). B-D) Glucose tolerance tests (GTT) and Area Under the Curve Glucose (AUC) from wt and ob/ob and db/db mice described in A. (B and C: Wt Con (dark blue line) and Wt Con + AC261 (light blue line) groups are repeated in GTT experiments in Fig 1B and 1C). E) Fasting glucose levels in wt and ob/ob mice described in A. F) Fasting insulin, G) insulin secretion, and H) AUC insulin of ob/ob mice subjected to ITT. I-L) Insulin tolerance testing (ITT) and ITT AUC glucose levels of ob/ob and db/db mice described in A. Errors bars represent ± SEM. *=p < 0.05, **=p < 0.01, ***=p < 0.001, ****=p < 0.0001.