A) Fasting glucose levels of wt C57/Bl6 male mice after 16 weeks of being fed either: a standard control chow (13% Kcal/fat) diet (Wt Con, n=4); a high fat (45%Kcal/fat) diet (HFD, n=5); or Con chow plus HFD with the RARβ2 agonist, AC261066 (Wt Con + AC261, n=3, Wt HFD + AC261, n=4) or another RARβ2 agonist, AC55649 (Wt Con + AC556, n=3, Wt HFD + AC556, n=4), in their drinking water. B) Glucose tolerance tests (GTT) and C) Area under the curve (AUC) glucose from mice described in A. D) Body weights of mice described in A. Errors bars represent ± SEM. ***=p < 0.0001.