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. 2016 Jul 18;11(7):e0159093. doi: 10.1371/journal.pone.0159093

Fig 1. Chronic unpredictable mild stress (CUMS) leads the mice to express depression-like behaviors.

Fig 1

Mice were subjected to the adaptation for a week, the CUMS for three weeks and the behavioral tests in three days. Behavior tests showed the significant decreases in sucrose preference (a) and the ratios of stay time in M-arm to stay time in three arms (b) as well as the increase in immobile time (c) from CUMS-induced depression mice (n = 10) and controls (n = 11). The results are expressed as mean ± SEM. *p<0.05, **p<0.01, ***p<0.001.