Table 1. Ranking of processes of RCN in terms of sensitivity of system to corresponding parameter change.

Rank	Reaction number	Parameter	Avg. sensitivity
1)	9	ν9	0.6
2)	0 (b)	TCF0	0.59
3)	6	K6	0.53
4)	12 (b)	KTmRNA	0.45
5)	0 (c)	(Axin/GSK3)0	0.43
6)	7	k7	0.43
7)	12 (a)	Tmax	0.42
8)	14	Pmax	0.42
9)	15	ν15	0.37
10)	17	k17	0.36
11)	5	k5	0.35
12)	11	K11	0.31
13)	13	k13	0.3
14)	19	k19	0.3
15)	2	K2	0.29
16)	1	K1	0.26
17)	4	k4	0.26
18)	18	k18	0.26
19)	16	k16	0.26
20)	20 (b)	Vmax t/Gmax	0.14
21)	20 (c)	KM	0.06
22)	3 (a)	k3	0.03
23)	0 (a)	APC0	0.03
24)	8	K8	0.02
25)	3 (b)	k-3	0.02
26)	20 (a)	ν20	0.0017
27)	22	k22	0.0016
28)	25	k25	0.0006
29)	26	k26	0.0005
30)	10	k10	0.0002
31)	21	K21	0
32)	23	k23	0

Ranking of parameters based on average relative sensitivity values over all variables. Reaction number refers to the numbering scheme used in Fig 2 to describe all processes of the RCN: “0” is used to label parameters describing total amount of conserved molecules, while letters are used to differentiate between parameters that describe a single processes. For a detailed mathematical description of the system and their precise definition, see Appendix A in S1 Text.