Table 2.
Some chemotherapeutic compounds and relationship with MMR substrate recognition
| Compound | Does MMR recognition mediate toxicity? | References |
|---|---|---|
| N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) | YES | 57, 84 |
| 6-thioguanine | YES | 58 |
| cisplatin, carboplatin | YES | 60–62 |
| oxaliplatin, tetraplatin, transplatin, JM335, and JM216 | NO | 60 |
| 8-azaguanine | NO | 58 |
| 5-fluorouracil | YES | 68 |
| doxorubicin, epirubicin, mitoxantrone | YES | 64 |
| bleomycin | NO | 85 |
| dacarbazine | YES | 86 |
| irinotecan/camptothecin, topotecan | NO | 63–65 |
| docetaxel, paclitaxel | NO | 64 |
| mitomycin C | NO | 87 |