Plasma RIP3 concentration at presentation (white boxes) and 48 hours (gray boxes) by RBC units transfused during resuscitation (day of and day after presentation). Thirty-four subjects received no transfusions, 26 received 1-5 units, 20 received >5 units. *p<0.001 for difference between presentation and 48 hours. Pairwise comparisons for plasma RIP3 concentrations at presentation: 1-5 RBC units v. no RBC units, p=0.074; >5 RBC units v. no RBC units, p=0.629; >5 RBC units v. 1-5 RBC units, p=0.094. Pairwise comparisons for plasma RIP3 concentrations at 48 hours: 1-5 RBC units v. no RBC units, p=0.004; >5 RBC units v. no RBC units, p<0.001; >5 RBC units v. 1-5 RBC units, p=0.051.