Table 2.
Cox model stratified by histology identifying predictors of overall mortality (2-year survival)
| Variable | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | |
| ET vs. surgery | 0.57 (0.43, 0.77) | 0.0002 | 0.51 (0.36, 0.73) | 0.0002 |
| Age at diagnosis | 1.04 (1.02, 1.06) | <0.0001 | 1.07 (1.04, 1.09) | <0.0001 |
| Female gender vs. male | 0.80 (0.61, 1.04) | 0.10 | 0.75 (0.55, 1.03) | 0.07 |
| Black/Other race vs. white | 1.18 (0.81, 1.71) | 0.40 | 1.10 (0.71, 1.71) | 0.67 |
| Tis vs. T1a | 0.55 (0.38, 0.81) | 0.002 | 0.65 (0.44, 0.98) | 0.04 |
| Charlson Score | ||||
| 0 | Reference | Reference | ||
| 1 | 1.08 (0.84, 1.40) | 0.55 | 1.10 (0.81, 1.49) | 0.54 |
| ≥2 | 1.52 (1.01, 2.29) | <0.05 | 1.54 (0.93, 2.53) | 0.09 |
| Receipt of radiation | 1.74 (1.36, 2.21) | <0.0001 | 1.52 (1.14, 2.03) | 0.004 |
| SEER Registry Region | ||||
| Northeast | Reference | Reference | ||
| Midwest | 1.12 (0.78, 1.62) | 0.54 | 1.20 (0.68, 2.10) | 0.53 |
| South | 1.56 (1.13, 2.15) | 0.007 | 1.59 (0.97, 2.60) | 0.07 |
| West | 1.15 (0.87, 1.54) | 0.33 | 1.40 (0.85, 2.31) | 0.19 |
| Education† | ||||
| Q1: 0–<13.6 | 1.70 (1.21, 2.40) | 0.002 | 0.91 (0.49, 1.71) | 0.77 |
| Q2: 13.6–<18.5 | 1.41 (1.01, 1.97) | <0.05 | 1.19 (0.71, 1.99) | 0.52 |
| Q3: 18.5–<23.2 | 1.60 (1.17, 2.18) | 0.003 | 1.42 (0.93, 2.16) | 0.10 |
| Q4: 23.2–45.7 | Reference | Reference | ||
| Income‡ | ||||
| Q1: $0–<$46,452 | 1.76 (1.29, 2.42) | 0.0004 | 2.01 (1.09, 3.72) | 0.03 |
| Q2: $46,452–<$53,438 | 1.47 (1.08, 2.01) | 0.02 | 1.07 (0.63, 1.80) | 0.81 |
| Q3: $53,438–<$63,611 | 1.26 (0.91, 1.74) | 0.16 | 0.99 (0.61, 1.62) | 0.97 |
| Q4: ≥$64,611 | Reference | Reference | ||
| Gastroenterologist density (per 1,000 residents) | ||||
| Q1: 0–<0.026 | 1.23 (0.91, 1.67) | 0.18 | 0.94 (0.58, 1.55) | 0.82 |
| Q2: 0.026–<0.042 | 0.95 (0.69, 1.30) | 0.73 | 0.91 (0.57, 1.44) | 0.68 |
| Q3: 0.042–<0.066 | 1.17 (0.87, 1.58) | 0.30 | 1.11 (0.74, 1.66) | 0.61 |
| Q4: 0.066–0.183 | Reference | Reference | ||
| Primary Care Provider Density (per 1,000 residents) | ||||
| Q1: 0–<0.183 | 1.11 (0.81, 1.50) | 0.52 | 0.95 (0.47, 1.94) | 0.89 |
| Q2: 0.183–<0.263 | 1.16 (0.85, 1.58) | 0.36 | 1.29 (0.71, 2.33) | 0.41 |
| Q3: 0.263–<0.352 | 1.03 (0.76, 1.39) | 0.86 | 1.63 (1.01, 2.63) | 0.04 |
| Q4: 0.352–0.851 | Reference | Reference | ||
| Diagnosis 2002–2009 vs. 1994–2001 | 0.63 (0.50, 0.78) | <0.0001 | 0.62 (0.47, 0.81) | <0.001 |
ET, Endoscopic Treatment
HR, Hazard Ratio
CI, Confidence Interval
Q, Quartile
†
Mean % residents in zip code with college education
‡
Mean zip code median income