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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Crit Care Med. 2016 Aug;44(8):e639–e650. doi: 10.1097/CCM.0000000000001629

Fig. 7. Schematic representation shows a miR-126a-3p mechanism of sepsis-related injuries on vascular ECs and vascular integrity.

Fig. 7

Endotoxemia in sepsis is able to downregulate the expression of EC-enriched miR-126a-3p in the vascular walls via KLF2. The downregulation of miR-126a-3p could induce endothelial dysfunction, and vascular leakage via their target genes such as SPRED1 and VCAM-1 that could induce vascular injury, irreversible multi-organ failure and sepsis-related death.