Table 1. miRNAs regulate M1 and M2 polarization through targeting various adaptor proteins and transcription factors.

MiRNAs	Phenotype promoted	Targets	Function	Ref.
miR-21	M2	SIRPb1	Promotes M2 polarization, downstream of CSF-1R	[42]
miR-21	M1	STAT3	Prevents PGE2-Mediated M2 polarization	[43]
miR-9	M1	PPAR-δ	Suppresses anti-inflammatory response	[45]
miR-127	M1	Bcl6	Promotes M1 phenotype through activation of JNK pathway	[46]
miR-155	M1	????	Promotes pro-inflammatory responses via JNK pathway	[47]
		C/EBPβ	Inhibits M2 polarization	[49]
		SOCS1	Promotes pro-inflammatory responses via P13K/Akt1 pathway	[50]
miR-125b	M1	IRF4	Enhances pro-inflammatory responses	[51]
miR-124	M2	STAT3, TACE	Inhibits production of pro-inflammatory cytokines	[52]
miR-223	M2	STAT3	Promotes anti-inflammatory response	[54]
miR-34a	M2	Notch1	Inhibits production of pro-inflammatory cytokines	[56]
Let-7c	M2	PAK1	Inhibits activation of NF-κB pathway	[57]
		C/EBP-δ	Promotes M2 phenotype	[58]
miR-132	M2	AChE	Promotes cholinergic anti-inflammatory response	[59]
miR-146a	M2	IRAK1,TRAF6	Prevents activation of NF-κB	[61]
miR-125a-5p	M2	KLF4	Promotes M2 polarization	[62]