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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Biol Psychiatry. 2016 Jan 18;81(1):67–77. doi: 10.1016/j.biopsych.2015.12.028

Figure 3. Examples of important experimental D1 agonists.

Figure 3

[Top Row] SKF-38393 (partial agonist) and SKF-82958 (full agonist) are phenylbenzazepines. SKF-89626 had higher intrinsic activity than SKF-38393, but lacked BBB permeability. CY208243 is a high D1 intrinsic activity ergoline. [Bottom row] Four full D1 agonists from four different chemotypes: A-77636, A-86829 (the active compound of the diacetyl prodrug ABT-431), dihydrexidine (DAR-0100A), and dinapsoline. The most pharmacologically active isomer is shown in all cases, although these compounds are sometimes used as racemates.