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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Biol Psychiatry. 2016 Jan 18;81(1):67–77. doi: 10.1016/j.biopsych.2015.12.028

Figure 4. Structures of D1 positve allosteric modulators (PAMs).

Figure 4

PAMs may offer an advantage over orthosteric (direct) agonists by interacting with endogenous dopamine tone, and as such, may possibly avoid biphasic effects currently seen with direct D1 agonists.