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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Hippocampus. 2016 Apr 4;26(8):1008–1020. doi: 10.1002/hipo.22583

Figure 2.

Figure 2

Egr1 in the dentate gyrus. A. Basal levels of Egr1 mRNA are similar in adult rats (n=3) and aged rats (n=3), as measured by RT-PCR (p > 0.05). B. The proportion of dentate granule cells that transcribe Egr1 under resting conditions are similar in adult and aged rats (p > 0.05). C. Representative confocal images from the dentate gyrus in adult and aged rats under rest conditions. Green = Egr1, Blue = cell nuclei stained with TOPRO. Magnification = 40×. D. Behavior-induced relative levels of Egr1 mRNA are significantly lower in aged rats (n=6) compared to adult rats (n=6), as measured by RT-PCR (*p = 0.005). E. The proportion of dentate granule neurons that transcribe Egr1 after exploration is significantly lower in aged rats (*p = 0.030). Representative confocal images from the dentate gyrus of behavior-treated rats in both age groups are shown in F. Green = Egr1, Blue = cell nuclei stained with TOPRO. Magnification = 40×. Scale bar = 20 µm.