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Feedback regulation of origin firing maintains telomere length homeostasis. At long telomeres, local Rif1 binding to telomere DNA (blue helix) blocks origin firing at proximal telomeres in adjacent DNA (black helix). The telomere is then replicated from the more distal Ori 1. At short telomeres, the fewer binding sites for Rif1 allows Ori 2 firing and this increases the probability of telomere extension.
