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. 2016 Jul 1;30(13):1503–1508. doi: 10.1101/gad.281188.116

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© 2016 Esposito et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Snail exploits intrinsic pauses in transcription. Blue lines represent successive transcriptional bursts (levels, Y-axis; time, X-axis). Successive bursts are interrupted by mitotic silencing (“mitosis” above the diagram) or inherent refractory phases between bursts. (A) The Snail repressor is absent in the ectoderm, and there are successive bursts during nc14 following mitotic silencing. (B,C) In the mesoderm, the Snail repressor either prevents reactivation of transcription at the onset of nc14 (C) or inhibits successive bursts during nc14 (B). (D) Raw sog>MS2 fluorescence intensity traces for individual nuclei in the ectoderm (top panel), near the mesoderm/ectoderm boundary (middle panel), or within the mesoderm (bottom panel).