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mTOR and insulin signaling collaborate to modulate intestinal fat mobilization. Hypodermal developmental timing genes engage mTORC2 signaling in the intestine to direct the expression of the vit genes. The model illustrates the genetic interactions identified in this study as well as those described elsewhere (Baumeister et al. 2006). Two alternative hypotheses (direct and indirect) are presented for the mechanism by which PQM-1 may regulate vitellogenesis.
