Table 2.
The changes of body weight colon length and histopathology of mice in each group.
| Group | Control | 1 mg 5-HT | 2 mg 5-HT | 1% DSS | 1% DSS + 1 mg 5-HT | 2.5% DSS |
|---|---|---|---|---|---|---|
| n | 8 | 9 | 9 | 14 | 12 | 7 |
| Change of BW (%)¶ | 2.1 ± 2.4 | 1.8 ± 1.8 | 0.9 ± 3.3 | −5.9 ± 4.2∗ | −19.0 ± 5.9∗ | −21.6 ± 5.9∗ |
| Colon length (cm) | 7.8 ± 0.5 | 7.6 ± 0.3 | 7.4 ± 0.4 | 6.4 ± 0.6∗ | 5.2 ± 0.7∗ | 4.9 ± 0.5∗ |
| Colon H&E staining scores | 0.1 ± 0.1 | 0.3 ± 0.1 | 0.4 ± 0.2 | 6.3 ± 0.9∗ | 10.7 ± 2.5∗ | 11.6 ± 1.9∗ |
¶Change of BW presents the change of mouse body weight at day 6.
∗ P < 0.05 versus control mice.